产品货号:
Z24234
中文名称:
PRDX3抗体
英文名称:
Anti-PRDX3 Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称 | Anti-PRDX3 Antibody |
指标别名 | Antioxidant protein 1;AOP 1;AOP1;HBC189;MER5;Peroxiredoxin 3;Peroxiredoxin III;PRDX3;PRO1748;Protein MER5 homolog;Prx III;PRX3;SP 22 |
克隆性 | Polyclonal |
检验物种 | human,mouse,rat |
应用范围 | WB,IHC,ICC/IF,FCM(Intracellular) |
基因名称 | PRDX3 |
抗体来源 | Rabbit |
抗体类型 | IgG |
免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of mouse Peroxiredoxin 3(240-257aa TIKPSPTASKEYFEKVHQ),identical to the related rat sequence,and different from the related human sequence by three amino acids. |
实际分子量 | 26KD |
成分 | 500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol. |
纯化方式 | Immunogen affinity purified. |
浓度 | 500μg/mL |
产品形态 | 溶液 |
保存条件 | 12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
背景资料 | PRDX3(peroxiredoxin 3) also known as AOP-1,MER5,SP-22 or PRX3,is localized exclusively in mitochondria.The deduced 256-amino acid human AOP1 protein shares 86% amino acid sequence similarity with mouse Aop1,and significant similarity with both the human proliferation-associated gene A product and the mouse stress-induced peritoneal macrophage protein Msp23.The PRDX3 gene is mapped on 10q26.11.Expression of PRDX3 is induced by MYC and is reduced in c-myc -/- cells.Chromatin immunoprecipitation analysis spanning the entire PRDX3 genomic sequence revealed that MYC binds preferentially to a 930-bp region surrounding exon 1.Results using mitochondria-specific fluorescent probes demonstrated that PRDX3 is essential for maintaining mitochondrial mass and membrane potential in transformed rat and human cells.These data provided evidence that PRDX3 is a MYC target gene that is required to maintain normal mitochondrial function. |
Uniprot ID | P20108 |
推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
基因名全称 | peroxiredoxin 3 |
蛋白名全称 | Thioredoxin-dependent peroxide reductase,mitochondrial |
推荐稀释比 | Western blot (WB) 1:500~2000 Immunohistochemistry in paraffin section (IHC) 1:50~400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50~400 Flow Cytometry(Intracellular) 1~3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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